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Transposon sequencing identifies genes impacting Staphylococcus aureus invasion in a human macrophage model

7 Sept 2023

Abstract excerpt

ABSTRACT Staphylococcus aureus is a facultative intracellular pathogen in many host cell types, facilitating its persistence in chronic infections. The genes contributing to intracellular pathogenesis have not yet been fully enumerated. Here, we cataloged genes influencing S. aureus invasion and survival within human THP-1 derived macrophages using two laboratory strains (ATCC2913 and JE2). We developed an in...

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PMID: 37676013
DOI: 10.1128/iai.00228-23

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