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Article

Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio.

Developmental and comparative immunology - 1 Apr 2004

Altmann Stephen M, Mellon Mark T, Johnson Marc C, Paw Barry H, Trede Nikolaus S, Zon Len I, Kim Carol H

Abstract excerpt

Type I interferons (IFNs) represent a crucial component of the innate immune response to viruses. An important downstream effector of IFN is the Mx gene, which is activated solely through this pathway. Mx proteins are characterized by a tripartite GTP-binding domain, dynamin family signature, and leucine zipper motif. Mx genes are transcribed upon activation of an interferon-stimulated response element (ISRE)...

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PMID: 14698216
DOI: 10.1016/j.dci.2003.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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