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Article

Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis.

Annual review of biochemistry - 1 Jan 2005

Valentine Joan Selverstone, Doucette Peter A, Zittin Potter Soshanna

Abstract excerpt

Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein) is an abundant copper- and zinc-containing protein that is present in the cytosol, nucleus, peroxisomes, and mitochondrial intermembrane space of human cells. Its primary function is to act as an antioxidant enzyme, lowering the steady-state concentration of superoxide, but when mutated, it can also cause disease. Over 100 different mutations have been...

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PMID: 15952898
DOI: 10.1146/annurev.biochem.72.121801.161647

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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