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Article

Joint effects of topoisomerase alterations and plasmid-mediated quinolone-resistant determinants in Salmonella enterica Typhimurium.

Microbial drug resistance (Larchmont, N.Y.) - 1 Mar 2011

Luo Yanping, Li Jingyun, Meng Yang, Ma Yue, Hu Changqin, Jin Shaohong, Zhang Qingsheng, Ding Hong, Cui Shenghui

Abstract excerpt

Alterations in topoisomerases and plasmid-mediated quinolone-resistant (PMQR) determinants have been identified as main quinolone-resistant mechanisms in Salmonella enterica Typhimurium. But the joint effects of these mechanisms have not been thoroughly characterized in homologous Salmonella Typhimurium strains. In this study, isogenic topoisomerase mutants were constructed using phage λ Red recombinase system...

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PMID: 20818995
DOI: 10.1089/mdr.2010.0074

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