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Article

UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.

Developmental biology - 1 Apr 2003

Merz David C, Alves Georges, Kawano Takehiro, Zheng Hong, Culotti Joseph G

Abstract excerpt

The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidance system. These unc-52 alleles do not cause circumferential DTC migration defects in an...

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PMID: 12654300
DOI: 10.1016/s0012-1606(03)00014-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.PMID 12654300Read ↗

Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.Semantic proximity Read ↗

The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.Semantic proximity Read ↗

Mutations in the sup-38 gene of Caenorhabditis elegans suppress muscle-attachment defects in unc-52 mutants.Semantic proximity Read ↗

Mutations in the unc-52 gene responsible for body wall muscle defects in adult Caenorhabditis elegans are located in alternatively spliced exons.Semantic proximity Read ↗

The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.Semantic proximity Read ↗

Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.Semantic proximity Read ↗

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.Semantic proximity Read ↗

C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.Semantic proximity Read ↗

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.Semantic proximity Read ↗

C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.Semantic proximity Read ↗

SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans.Semantic proximity Read ↗

Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.Semantic proximity Read ↗

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