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Article

The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.

Biochemical and biophysical research communications - 1 Jan 2022

Qiu Zhongqiang, Park Aileen, Wang Lianzijun, Wilsey Rachel, Lee Myeongwoo

Abstract excerpt

UNC-52/perlecan is a basement membrane (BM) proteoglycan playing an essential role in the muscle cell attachment of C. elegans. The UNC-52 protein contains two RGD (Arg-Gly-Asp) motifs in domains III and IV, a well-characterized tripeptide known for binding to mammalian β integrin. To investigate the role of the RGD motif in UNC-52/perlecan, we created two mutations in the 2021RGD2023 motif: one mutation changed...

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PMID: 34844120
DOI: 10.1016/j.bbrc.2021.11.083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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