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Article

Hippocampal synaptic plasticity in mice carrying the rd mutation in the gene encoding cGMP phosphodiesterase type 6 (PDE6).

Brain research - 28 Mar 2003

Kuenzi Frederick, Rosahl Thomas W, Morton Robin A, Fitzjohn Stephen M, Collingridge Graham L, Seabrook Guy R

Abstract excerpt

Cyclic GMP (cGMP) has been implicated in the modulation of long-term potentiation (LTP) and depression (LTD) in the hippocampus. Transcripts for subunits of several types of cGMP specific phosphodiesterase are found in the mammalian brain but their relative role in hippocampal function is unclear. The retinal degeneration (rd) mutation in the gene encoding the PDE6B subunit causes a loss of function in PDE6...

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Identifiers

PMID: 12650975
DOI: 10.1016/s0006-8993(02)04241-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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