Article
Loss of Pde6 reduces cell body Ca(2+) transients within photoreceptors.
Cell death & disease - 12 Sept 2013
Ma E Y, Lewis A, Barabas P, Stearns G, Suzuki S, Krizaj D, Brockerhoff S E
Abstract excerpt
Modulation of Ca(2+) within cells is tightly regulated through complex and dynamic interactions between the plasma membrane and internal compartments. In this study, we exploit in vivo imaging strategies based on genetically encoded Ca(2+) indicators to define changes in perikaryal Ca(2+) concentration of intact photoreceptors. We developed double-transgenic zebrafish larvae expressing GCaMP3 in all cones and...
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