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Article

Very late relapse in diffuse large B-cell lymphoma represents clonally related disease and is marked by germinal center cell features

25 Mar 2003

Abstract excerpt

Patients with diffuse large B-cell lymphoma (DLBCL) rarely show relapse after 4 years of complete remission (CR). In this study, we addressed the following questions: (1) Does late-relapsing DLBCL represent clonally related disease or a second malignancy; and (2) is there a characteristic biologic background? In 10 of 13 DLBCL patients with relapse after 4 to 17 years, a clonal relationship was established based...

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PMID: 12649152
DOI: 10.1182/blood-2002-09-2822

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