Article
Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice.
International journal of oncology - 1 Sept 2007
Akutsu Yasunori, Matsubara Hisahiro, Urashima Tetsuro, Komatsu Aki, Sakata Haruhito, Nishimori Takanori, Yoneyama Yasuo, Hoshino Isamu, Murakami Kentaro, Usui Akihiro, Kano Masayuki, Ochiai Takenori
Abstract excerpt
We tested a new therapeutic modality for head and neck and esophageal cancers, a combination of direct intratumoral (i.t.) administration of dendritic cells (DCs) and radiation therapy (RT) in mouse squamous cell carcinoma (SCC). We also evaluated the functions of gp96, which can enhance systemic antitumor activity, and the mechanism of the abscopal effect. Mouse SCC cells (1 x 10(5)), SCCVII, were inoculated...
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