Article
Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division.
Developmental biology - 15 Jan 2003
Park Youngji, Rangel Carolina, Reynolds M Megan, Caldwell M Craig, Johns Misty, Nayak Mamatha, Welsh C Jane R, McDermott Sean, Datta Sumana
Abstract excerpt
Mutations in the Drosophila trol gene cause cell cycle arrest of neuroblasts in the larval brain. Here, we show that trol encodes the Drosophila homolog of Perlecan and regulates neuroblast division by modulating both FGF and Hh signaling. Addition of human FGF-2 to trol mutant brains in culture rescues the trol proliferation phenotype, while addition of a MAPK inhibitor causes cell cycle arrest of the regulated...
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