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Article

Expression of cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system.

Mechanisms of development - 1 Dec 1998

Caldwell M C, Datta S

Abstract excerpt

The trol locus of Drosophila regulates the timing of neuroblast proliferation. In trol mutants, quiescent neuroblasts fail to begin division. We have investigated this cell cycle arrest to examine trol function. Induced expression of cyclin E or DP/E2F in trol mutants results in normal levels of dividing neuroblasts, while cyclin B expression has no effect. cyclin E expression is lower in the trol mutant larval...

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PMID: 10349625
DOI: 10.1016/s0925-4773(98)00178-6

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