Article
Loss of RPE phenotype affects phagocytic function.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Mar 2003
Feng Wei, Zheng Jing J, Lutz Douglas A, McLaughlin Barbara J
Abstract excerpt
BACKGROUND: Cultured retinal pigment epithelial (RPE) cells exposed to vitreous lose their cuboidal epithelial phenotype and transform to a fibroblast-like morphology. This study investigates whether the loss of RPE phenotype will affect the ability of RPE to phagocytize photoreceptor outer segments (ROS). METHODS: First-passage porcine RPE cells were grown to confluence and exposed to an equal mixture of freshly...
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