Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype.

American journal of physiology. Renal physiology - 1 Jul 2003

Tian Ya-Chung, Fraser Donald, Attisano Liliana, Phillips Aled O

Abstract excerpt

The aim of this study was to characterize the mechanism of transforming growth factor (TGF)-beta1-mediated alteration of renal proximal tubular cell phenotype. TGF-beta1 altered cell phenotype, with cells appearing elongated and spindle shaped. This was associated with loss of cell-cell contact and rearrangement of the actin cytoskeleton, increased formation of stress fibers, and focal adhesions. Addition of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adherens Junctions
Share to Cell Size
Share to Kidney Tubules, Proximal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to rho-Associated Kinases

Share to rhoA GTP-Binding Protein

Share to Smad Proteins

Share to Tight Junctions

Share to Wnt Proteins

Source

Identifiers

PMID: 12644442
DOI: 10.1152/ajprenal.00408.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype.PMID 12644442Read ↗

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.Semantic proximity Read ↗

Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.Semantic proximity Read ↗

Role of proteoglycans and cytoskeleton in the effects of TGF-beta 1 on renal proximal tubule cells.Semantic proximity Read ↗

Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.Semantic proximity Read ↗

Differential regulation of E-cadherin and α-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosisSemantic proximity Read ↗

Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling.Semantic proximity Read ↗

Rho/Rho kinase pathway regulates maintenance of the differentiated tubular epithelial cell phenotype on laminin-1.Semantic proximity Read ↗

Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells.Semantic proximity Read ↗

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.Semantic proximity Read ↗

Localisation and phenotypical characterisation of collagen-producing cells in TGF-beta 1-induced renal interstitial fibrosis.Semantic proximity Read ↗

Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro.Semantic proximity Read ↗

Smad mediated regulation of inhibitor of DNA binding 2 and its role in phenotypic maintenance of human renal proximal tubule epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.