Article
Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene.
Oncogene - 20 Mar 2003
Nasr Ashraf F, Nutini Michele, Palombo Barbara, Guerra Emanuela, Alberti Savenio
Abstract excerpt
p53 and DNA methylation play key roles in the maintenance of genome stability. In this work, we demonstrate that the two mechanisms are linked and that p53 plays a role in the maintenance of the DNA methylation levels. The loss of p53 was shown to induce loss of DNA methylation in the TROP1 gene, a human cancer-expressed locus that undergoes amplification when hypomethylated. This demethylation was reverted by...
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