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Article

PRIMA-1 selectively induces global DNA demethylation in p53 mutant-type thyroid cancer cells.

Journal of biomedical nanotechnology - 1 Jul 2014

Qiang Wei, Jin Tianbo, Yang Qi, Liu Wei, Liu Shu, Ji Meiju, He Nongyue, Chen Chao, Shi Bingyin, Hou Peng

Abstract excerpt

The p53 tumor suppressor pathway blocks carcinogenesis by triggering apoptosis and cellular senescence in response to oncogenic stress. Over 50% of human cancers including thyroid cancer carry loss-of-function mutations in the p53 gene. Recently, the identification of mutant p53-reactivating smal...

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Source

Identifiers

PMID: 24804545
DOI: 10.1166/jbn.2014.1862

Genes

TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24804545-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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PRIMA-1 selectively induces global DNA demethylation in p53 mutant-type thyroid cancer cells.PMID 24804545Read ↗

Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells.Semantic proximity Read ↗

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.Semantic proximity Read ↗

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Epigenetic Silencing of TET1 Mediated Hydroxymethylation of Base Excision Repair Pathway During Lung CarcinogenesisSemantic proximity Read ↗

Thyroid carcinoma is characterized by genomic instability: evidence from p53 mutations.Semantic proximity Read ↗

PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic AgentSemantic proximity Read ↗

PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein.Semantic proximity Read ↗

Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell DeathSemantic proximity Read ↗

Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.Semantic proximity Read ↗

PRIMPOL and POLI Deficiencies Differentially Affect DNA Repair and Post-Irradiation Survival of Non-Small Cell Lung Cancer Cell LinesSemantic proximity Read ↗

PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.Semantic proximity Read ↗

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