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Article

Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by beta1-integrin signaling pathways.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2003

Wernig Florian, Mayr Manuel, Xu Qingbo

Abstract excerpt

Recently we demonstrated that mechanical stress induces apoptosis of vascular smooth muscle cells in vitro and in vein grafts (Mayr et al. FASEB J. 2000;15:261-270). The current study was designed to investigate molecular mechanisms of mechanical stretch-induced apoptosis. Smooth muscle cells cultivated on silicone elastomer plates precoated with collagen I, elastin, laminin, or Pronectin were subjected to cyclic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12642506
DOI: 10.1161/01.HYP.0000062882.42265.88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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