Article
Collagen suppresses the proliferative phenotype of allylamine-injured vascular smooth muscle cells.
Atherosclerosis - 1 Jun 2002
Wilson Emily, Parrish Alan R, Bral Christopher M, Williams E Spencer, Ramos Kenneth S
Abstract excerpt
Repeated cycles of oxidative injury by allylamine induce proliferative rat vascular smooth muscle cell (vSMC) phenotypes characterized by enhanced secretion of osteopontin (OPN). The present study was designed to evaluate the role of extracellular matrix (ECM) interactions in the induction of proliferative phenotypes in this model of oxidant injury. Because OPN is involved in ECM/integrin signaling, and may...
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