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Article

Inhibiting Ras signaling in the therapy of breast cancer.

Clinical breast cancer - 1 Feb 2003

Li Tianhong, Sparano Joseph A

Abstract excerpt

Ras is a small guanosine triphosphate-binding protein that plays an important role in signal transduction pathways that influence cellular proliferation, apoptosis, cytoskeletal organization, and other important biological processes. Prenylation of Ras proteins by the enzyme farnesyltransferase renders the protein hydrophobic, causing localization to the inner surface of the cell membrane, where it exerts its...

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Identifiers

PMID: 12636885
DOI: 10.3816/CBC.2003.n.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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