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Article

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

1 Sept 2000

Abstract excerpt

A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at the molecular level allows the design of rational, mechanism-based therapeutic agents that...

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Identifiers

PMID: 10961860
DOI: 10.1182/blood.v96.5.1655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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