Article
Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068.
International journal of cancer - 8 Oct 1999
Prevost G P, Pradines A, Viossat I, Brezak M C, Miquel K, Lonchampt M O, Kasprzyk P, Favre G, Pignol B, Le Breton C, Dong J, Morgan B
Abstract excerpt
Oncogenic mutations of the ras gene leading to constitutive activation of downstream effectors have been detected in a large spectrum of human cancers (pancreas, thyroid, colon and NSCLC). Membrane anchorage of Ras required for functional activity in signal transduction is facilitated by post-translational modifications resulting in covalent attachment of a farnesyl group to the cysteine in the C-terminal CAAX...
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