Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Farnesyltransferase Inhibitor as Anticancer Agent

30 May 2009

Abstract excerpt

Ras protein plays pivotal roles in control of normal and transformed cell growth. These ras genes are mutated in 30% of human cancer. For functioning of Ras protein its prenylation (farnesylation) is required. Therefore targeting Ras farnesylation is valuable approach for cancer treatment. Farnesyltransferase inhibitor (FTI) has been developed as anticancer drug and is currently evaluated in clinical trials....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Estrogen and related hormone effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19519490
DOI: 10.2174/138955709788452702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Farnesyltransferase Inhibitor as Anticancer AgentPMID 19519490Read ↗

RAS: Target for Cancer TherapySemantic proximity Read ↗

Farnesylated proteins as anticancer drug targets: from laboratory to the clinic.Semantic proximity Read ↗

Farnesyltransferase inhibitors: potential role in the treatment of cancer.Semantic proximity Read ↗

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.Semantic proximity Read ↗

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?Semantic proximity Read ↗

Evolving therapies: farnesyltransferase inhibitors.Semantic proximity Read ↗

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.Semantic proximity Read ↗

K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives.Semantic proximity Read ↗

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?Semantic proximity Read ↗

Ras farnesyltransferase: a new therapeutic target.Semantic proximity Read ↗

New tricks for human farnesyltransferase inhibitor: cancer and beyondSemantic proximity Read ↗

Perspectives on farnesyl transferase inhibitors in cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.