Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing of tissue factor pathway inhibitor‐2 gene in malignant melanomas

19 Mar 2007

Abstract excerpt

To identify tumor-suppressor genes inactivated by aberrant methylation of promoter CpG islands (CGIs) in human malignant melanomas, genes upregulated by treatment of cells with a demethylating agent, 5-aza-2'-deoxycytidine (5-aza-dC), were searched for using oligonucleotide microarrays in melanoma cell lines, HMV-I, MeWo and WM-115. Seventy-nine known genes with CGIs were identified as being upregulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cell Adhesion Molecules Research
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17372906
DOI: 10.1002/ijc.22637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Silencing of tissue factor pathway inhibitor‐2 gene in malignant melanomasPMID 17372906Read ↗

Tissue factor pathway inhibitor‐2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma†Semantic proximity Read ↗

The Role of Tissue Factor Pathway Inhibitor-2 in Cancer BiologySemantic proximity Read ↗

Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cellsSemantic proximity Read ↗

TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinomaSemantic proximity Read ↗

Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma developmentSemantic proximity Read ↗

Methylation of TFPI-2 gene is not the sole cause of its silencing.Semantic proximity Read ↗

Aberrant p27Kip1 promoter methylation in malignant melanoma.Semantic proximity Read ↗

Frequent hypermethylation of 5' flanking region of TIMP-2 gene in cervical cancer.Semantic proximity Read ↗

Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomasSemantic proximity Read ↗

FOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.