Article
Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype.
Immunology and cell biology - 1 Apr 2003
Linder Stefan, Wintergerst Uwe, Bender-Götze Christine, Schwarz Klaus, Pannicke Ulrich, Aepfelbacher Martin
Abstract excerpt
The immunodeficiency disorder Wiskott-Aldrich syndrome and its milder form X-linked thrombo-cytopenia are caused by mutations in the WASp gene. Wiskott-Aldrich syndrome is characterized by a plethora of clinical symptoms which are due to functional defects of haematopoietic cells, including the inability of macrophages to form actin-rich adhesion structures called podosomes. In contrast, X-linked thrombocytopenia...
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