Article
Failure of immunocompetitive capillary electrophoresis assay to detect disease-specific prion protein in buffy coat from humans and chimpanzees with Creutzfeldt-Jakob disease.
Electrophoresis - 1 Mar 2003
Cervenakova Larisa, Brown Paul, Soukharev Serguei, Yakovleva Oksana, Diringer Heino, Saenko Evgueni L, Drohan William N
Abstract excerpt
The emergence of a new environmentally caused variant of Creutzfeldt-Jakob disease (vCJD), the result of food-born infection by the causative agent of bovine spongiform encephalopathy (BSE), has stimulated research on a practical diagnostic screening test. The immunocompetitive capillary electrophoresis (ICCE) assay has been reported to detect disease-specific, proteinase-resistant prion protein (PrPres) in the...
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