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Article

Glutamate at the phosphorylation site of response regulator CtrA provides essential activities without increasing DNA binding.

Nucleic acids research - 15 Mar 2003

Siam Rania, Marczynski Gregory T

Abstract excerpt

The essential response regulator CtrA controls the Caulobacter crescentus cell cycle and phosphorylated CtrA approximately P preferentially binds target DNA in vitro. The CtrA aspartate to glutamate (D51E) mutation mimics phosphorylated CtrA approximately P in vivo and rescues non-viable C.crescentus cells. However, we observe that the CtrA D51E and the unphosphorylated CtrA wild-type proteins have identical DNA...

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Identifiers

PMID: 12626719
DOI: 10.1093/nar/gkg271
PMCID: PMC152873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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