Article
Disrupting NtrC function reveals unexpected robustness in a central cell cycle regulatory network.
mBio - 10 Sept 2025
North Hunter, Hydorn Molly, Dworkin Jonathan, Fiebig Aretha, Crosson Sean
Abstract excerpt
Cell cycle progression relies on coordinated signaling systems that integrate diverse cellular and environmental cues. In Caulobacter and related Alphaproteobacteria, the essential sensor histidine kinase CckA initiates a phosphorelay signaling cascade that controls both the transcriptional activity and proteolytic stability of the master cell cycle regulator, CtrA. To uncover regulatory connections between this...
Topics
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Cell Cycle
- Signal Transduction
- Transcription Factors
- Caulobacter crescentus
- Mutation
- DNA-Binding Proteins
- Histidine Kinase
- Caulobacter
- Glutamine