Article

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

2024-05-21

Abstract excerpt

The pre-mRNA processing factor 4 kinase (PRP4K) is an essential gene in animal cells, making interrogation of its function challenging. Here, we report the first knockout model for PRP4K in the social amoeba Dictyostelium discoideum, revealing a new function in splicing events controlling autophagy. When prp4k knockout amoebae underwent multicellular development, we observed defects in differentiation linked to ab...

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Literature Corpus work: 54148fad-9d30-52a9-a208-e9962e316802
DOI: 10.1101/2024.05.21.595022

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