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Article

Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis.

Thrombosis and haemostasis - 1 May 2004

Agema Willem R P, Wouter Jukema J, de Maat Moniek P M, Zwinderman Aeilko H, Kastelein John J P, Rabelink Ton J, van der Wall Ernst E

Abstract excerpt

Atherosclerosis is at least in part an inflammatory disease. CD14 is an endotoxin receptor that after binding of lipopolysaccharides evokes endothelial activation and secretion of several cytokines. A polymorphism of CD14 has been associated with myocardial infarction. We evaluated the role of the -159 T/C polymorphism in the promoter region of the CD14 gene in relation to severity and progression of coronary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15116260
DOI: 10.1160/TH03-11-0668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis.PMID 15116260Read ↗

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CD14 C(-260)T promoter polymorphism and prevalence of acute coronary syndromes.Semantic proximity Read ↗

CD14 promoter polymorphism (- 159C-->t) is not associated with myocardial infarction or coronary artery disease in patients with assumed high genetic risk.Semantic proximity Read ↗

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A polymorphism in the promoter of the CD14 gene (CD14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki disease.Semantic proximity Read ↗

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