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Article

An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing.

The EMBO journal - 16 Dec 2002

Rho Seung Bae, Lincecum Tommie L, Martinis Susan A

Abstract excerpt

Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron and collaborates with the bI4 maturase to aid excision of the group I intron. Deletion analysis isolated the inserted LeuRS CP1 domain as a critical factor in the protein's splicing activity. Protein fragments comprised of just the LeuRS CP1 region rescued complementation of a yeast strain that expressed a splicing-defective LeuRS....

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Identifiers

PMID: 12486008
DOI: 10.1093/emboj/cdf671
PMCID: PMC139092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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