Article
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
Human molecular genetics - 15 Mar 2003
Waite Kristin A, Eng Charis
Abstract excerpt
The tumour suppressor gene PTEN encodes a dual-specificity phosphatase that recognizes protein and phosphatidylinositiol substrates and modulates cellular functions such as migration and proliferation. Germline mutations of PTEN have been shown to cause Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome and Proteus syndrome. Recently, germline mutations in BMPR1A, the gene encoding the type 1A receptor of bone...
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