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PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner

15 Jan 2006

Abstract excerpt

PTEN (phosphatase and tensin homologue, deleted on chromosome 10) is a tumor suppressor with dual phosphatase activity and mutations of its gene, PTEN, have been associated with many sporadic cancers and heritable neoplasia syndromes, including Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. However, accumulating evidence now shows that PTEN may have novel functions other than as a phosphatase. In the...

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PMID: 16424003
DOI: 10.1158/0008-5472.can-05-1557

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PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent MannerPMID 16424003Read ↗

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Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome.Semantic proximity Read ↗

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