Article
Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: The experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents.
Cancer - 15 Sept 2017
Millot Frédéric, Dupraz Christelle, Guilhot Joelle, Suttorp Meinolf, Brizard Françoise, Leblanc Thierry, Güneş Adalet Meral, Sedlacek Petr, De Bont Evelyne, Li Chi Kong, Kalwak Krzysztof, Lausen Birgitte, Culic Srdjana, Dworzak Michael, Kaiserova Emilia, De Moerloose Barbara, Roula Farah, Biondi Andrea, Baruchel André, Guilhot François
Abstract excerpt
BACKGROUND: In the adult population with newly diagnosed chronic myeloid leukemia (CML), variant translocations are usually not considered to be impairing the prognosis, whereas some additional cytogenetic abnormalities (ACAs) are associated with a negative impact on survival. Because of the rarity of CML in the pediatric population, such abnormalities have not been investigated in a large group of children with...
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