Article
Extensive polymorphism and different evolutionary patterns of intron 2 were identified in the HLA-DQB1 gene.
Immunogenetics - 1 Feb 2003
Fu Yonggui, Liu Zehuan, Lin Jianghai, Chen Weimin, Jia Zongjian, Pan Dejing, Xu Anlong
Abstract excerpt
Exon 2 and intron 2 of the HLA DQB1 gene from 20 individuals were cloned and sequenced and eight alleles were obtained. Based on our analysis, the nucleotide diversity of the 5' end of intron 2 was higher than the synonymous nucleotide diversity of exon 2, which may be due to the lower GC content and the 'hitch-hiking effect'. In contrast, the opposite phenomenon was observed for the 3' end of intron 2, which may...
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