Article
Genetic diversity in exon 2 of the major histocompatibility complex class II DQB1 locus in Nigerian goats.
Biochemical genetics - 1 Dec 2013
Yakubu Abdulmojeed, Salako Adebowale E, De Donato Marcos, Takeet Michael I, Peters Sunday O, Adefenwa Mufliat A, Okpeku Moses, Wheto Mathew, Agaviezor Brilliant O, Sanni Timothy M, Ajayi Oyeyemi O, Onasanya Gbolabo O, Ekundayo Oludotun J, Ilori Babatunde M, Amusan Samuel A, Imumorin Ikhide G
Abstract excerpt
The DQB1 locus is located in the major histocompatibility complex (MHC) class II region and involved in immune response. We identified 20 polymorphic sites in a 228 bp fragment of exon 2, one of the most critical regions of the MHC DQB1 gene, in 60 Nigerian goats. Four sites are located in the peptide binding region, and 10 amino acid substitutions are peculiar to Nigerian goats, compared with published...
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