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Article

[The contribution of gene conversion at the same chromosome to the HLA diversity].

Yi chuan = Hereditas - 1 Nov 2008

Hao Xiang-Wen, Deng Li-Bin, Zeng Chang-Qing

Abstract excerpt

HLA is the most polymorphic gene family in human genome, which is imperative for human to face numerous heterogeneous bio-molecules. Previous studies on the formation of HLA polymorphism have been focused on gene crossover. Here, we investigated the contribution of gene conversion, which is an important mechanism to generate polymorphism at shaping different patterns of HLA-DRB genes. Analysis of all known...

Topics

Alleles
Asian People
Chromosomes, Human
DNA, Complementary
Exons
Gene Conversion
Genetic Variation
HLA-DR Antigens
Haplotypes
Humans
Polymorphism, Genetic
White People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19073548
DOI: 10.3724/sp.j.1005.2008.01411

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