Article
Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.
Vascular pharmacology - 1 Aug 2002
Bloemenkamp Kitty W M, de Maat Moniek P M, Dersjant-Roorda Marianne C, Helmerhorst Frans M, Kluft Cornelis
Abstract excerpt
Elevated plasma levels of factor VII and fibrinogen are risk factors for cardiovascular disease, especially arterial thrombosis. Oral contraceptive use increases factor VII and fibrinogen plasma levels. It has been described that DNA polymorphisms are associated with the plasma levels of hemostatic variables and their regulation. The R/Q353 polymorphism in the factor VII gene and the -455G/A polymorphism in the...
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