Article
Beta-adrenergic receptor polymorphisms in patients with elevated factor VIII levels with venous thrombosis.
British journal of haematology - 1 Oct 2003
O'Donnell James, Manning Richard A, Laffan Michael A
Abstract excerpt
Beta-blockers significantly reduce elevated factor VIII (FVIII) levels in patients with venous thromboembolism (VTE). To determine whether beta-adrenergic receptors are important in the aetiology of high FVIII levels, we investigated four coding polymorphisms of the beta1- and beta2-receptor genes in 64 patients with high FVIII and VTE and 100 healthy controls. Genotypic and allelic frequencies were not...
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