Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.

Abstract excerpt

Although a specific genotype may be associated in healthy subjects with modest differences in levels of a risk factor for thrombosis, this effect may be larger or smaller in subgroups of subjects. Documenting such gene-environment interactions is important if genotype information is ever to be used in a clinical or diagnostic setting, and understanding the molecular mechanisms of such interactions is vital to be...

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