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Article

Recognition of HLA‐G by the NK cell receptor KIR2DL4 is not essential for human reproduction

17 Feb 2003

Abstract excerpt

A central issue of reproductive immunology in mammals is why a semi-allogeneic embryo is not rejected by the pregnant mother. This is particularly intriguing since, in different species, the early pregnant uterus is infiltrated by numerous maternal lymphocytes, predominantly NK cells. The human NK cell receptor KIR2DL4 has been implicated in the maternal tolerance to the embryo due to its recognition of HLA-G, a...

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PMID: 12616484
DOI: 10.1002/eji.200323741

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Related research

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Recognition of HLA‐G by the NK cell receptor KIR2DL4 is not essential for human reproductionPMID 12616484Read ↗

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KIR2DL4 (CD158d): An activation receptor for HLA-GSemantic proximity Read ↗

Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention.Semantic proximity Read ↗

Possible Roles of KIR2DL4 Expression on uNK Cells in Human PregnancySemantic proximity Read ↗

Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in ReproductionSemantic proximity Read ↗

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and miceSemantic proximity Read ↗

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