Article
Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2003
Skogsberg Josefin, Kannisto Katja, Cassel Tobias N, Hamsten Anders, Eriksson Per, Ehrenborg Ewa
Abstract excerpt
OBJECTIVE: The objective of this work was to explore the role of peroxisome proliferator-activated receptor delta (PPARD) in lipid metabolism in humans. METHODS AND RESULTS: PPARD is a nuclear receptor involved in lipid metabolism in primates and mice. We screened the 5'-region of the human gene for polymorphisms to be used as tools in association studies. Four polymorphisms were detected: -409C/T in the promoter...
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