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Article

Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder.

Molecular psychiatry - 1 Feb 2003

Mundo E, Tharmalingham S, Neves-Pereira M, Dalton E J, Macciardi F, Parikh S V, Bolonna A, Kerwin R W, Arranz M J, Makoff A J, Kennedy J L

Abstract excerpt

There is evidence for the involvement of glutamatergic transmission in the pathogenesis of major psychoses. The two most commonly used mood stabilizers (ie lithium and valproate) have been found to act via the N-methyl-D-aspartate receptor (NMDAR), suggesting a specific role of NMDAR in the pathogenesis of bipolar disorder (BP). The key subunit of the NMDAR, named NMDA-1 receptor, is coded by a gene located on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Receptors, N-Methyl-D-Aspartate

Source

Identifiers

PMID: 12610658
DOI: 10.1038/sj.mp.4001218

Genes

GRIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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