Article
Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function.
Journal of cellular biochemistry - 1 Aug 2024
Da'as Sahar I, Thanassoulas Angelos, Calver Brian L, Saleh Alaaeldin, Abdelrahman Doua, Hasan Waseem, Safieh-Garabedian Bared, Kontogianni Iris, Nasrallah Gheyath K, Nounesis George, Lai F Anthony, Nomikos Michail
Abstract excerpt
Calmodulin (CaM) is a ubiquitous, small cytosolic calcium (Ca2+)-binding sensor that plays a vital role in many cellular processes by binding and regulating the activity of over 300 protein targets. In cardiac muscle, CaM modulates directly or indirectly the activity of several proteins that play a key role in excitation-contraction coupling (ECC), such as ryanodine receptor type 2 (RyR2), l-type Ca2+ (Cav1.2),...
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