Article
Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.
Journal of the American Heart Association - 2 May 2018
Liu Bin, Walton Shane D, Ho Hsiang-Ting, Belevych Andriy E, Tikunova Svetlana B, Bonilla Ingrid, Shettigar Vikram, Knollmann Bjorn C, Priori Silvia G, Volpe Pompeo, Radwański Przemysław B, Davis Jonathan P, Györke Sándor
Abstract excerpt
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2) and its auxiliary proteins including calsequestrin (CASQ2) and calmodulin (CaM). It has been suggested that impairment of the ability of RyR2 to stay...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.