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Abnormal Regulation of DNA Methyltransferase Expression in Cloned Mouse Embryos1

1 Jul 2003

Abstract excerpt

Cloning by somatic cell nuclear transfer is inefficient. This is evident in the significant attrition in the number of surviving cloned offspring at virtually all stages of embryonic and fetal development. We find that cloned preimplantation mouse embryos aberrantly express the somatic form of the Dnmt1 DNA (cytosine-5) methyltransferase, the expression of which is normally prevented by a posttranscriptional...

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PMID: 12606374
DOI: 10.1095/biolreprod.102.014076

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