A paradigm for direct stress-induced mutation in prokaryotes.

Abstract excerpt

Environmental stresses may lead to selection for hypermutator bacterial cells, which have an increased chance of generating beneficial variants. With stress removal, cost of mutation exceeds the fitness advantage, selecting against hypermutators. Hypermutators arise through several mechanisms, including inactivation of mismatch repair genes (MMR) or induction of error-prone polymerases. Helicobacter pylori may...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Oxidative Stress
• Share to Reactive Nitrogen Species