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Article

DNA Damage Triggers Genetic Exchange in Helicobacter pylori

29 Jul 2010

Abstract excerpt

Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA damage response, as...

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PMID: 20686662
DOI: 10.1371/journal.ppat.1001026

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