Article
The role of Vif during HIV-1 infection: interaction with novel host cellular factors.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Feb 2003
Lake Julie-anne, Carr Jillian, Feng Feng, Mundy Linda, Burrell Christopher, Li Peng
Abstract excerpt
BACKGROUND: Current research suggests that human immunodeficiency virus type-1 (HIV-1) virion infectivity factor (Vif) acts during viral assembly in producer cells to ensure infectivity in target cells but the exact mechanism of action has not been defined. Vif interacts with Gag, viral protease and RNA and these interactions are proposed to be important for correct particle assembly and stability of the reverse...
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