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Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription

1 Oct 2000

Abstract excerpt

The vif gene of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication, although the functional target of Vif remains elusive. HIV-1 vif mutant virions derived from nonpermissive H9 cells displayed no significant differences in the amount, ratio, or integrity of their protein composition relative to an isogenic wild-type virion. The amounts of the virion-associated viral genomic RNA and...

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PMID: 10982337
DOI: 10.1128/jvi.74.19.8938-8945.2000

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