Article
The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p.
Molecular biology of the cell - 1 Jan 2006
Moore Jeffrey K, D'Silva Sonia, Miller Rita K
Abstract excerpt
Accurate positioning of the mitotic spindle in Saccharomyces cerevisiae is coordinated with the asymmetry of the two poles and requires the microtubule-to-actin linker Kar9p. The asymmetric localization of Kar9p to one spindle pole body (SPB) and microtubule (MT) plus ends requires Cdc28p. Here, we show that the CLIP-170 homologue Bik1p binds directly to Kar9p. In the absence of Bik1p, Kar9p localization is not...
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